Perlonfo® NAD+ Cellular Renewal Complex（5-in-1） is formulated with five bioactive compounds: betaine anhydrous, β-nicotinamide mononucleotide (β-NMN), nicotinamide riboside chloride (NR-Cl), coenzyme Q10, and pyrroloquinoline quinone disodium salt (PQQ).
Oxidized nicotinamide adenine dinucleotide (NAD+), a ubiquitous coenzyme in living cells, serves as a critical regulator in energy metabolism, DNA repair mechanisms, cellular signaling pathways, and longevity-associated biological processes. Specifically, NAD+ participates in the tricarboxylic acid (TCA) cycle and oxidative phosphorylation cascade, facilitating adenosine triphosphate (ATP) biosynthesis to enhance cellular energy homeostasis.
β-Nicotinamide mononucleotide (β-NMN) has significant physiological efficacy in human cells by elevating intracellular NAD+ concentrations through the nicotinamide phosphoribosyltransferase (NAMPT)-mediated salvage pathway.
Nicotinamide riboside chloride (NR-Cl), a phosphorylatable NAD+ precursor, undergoes enzymatic conversion to NAD+ via the nicotinamide riboside kinase (NRK) pathway. Recent studies from Harvard University validate that the synergistic combination of β-NMN and NR-Cl constitutes a safe and effective dual-precursor strategy for systemic NAD+ replenishment.
The formulation incorporates betaine anhydrous（Trimethylamine N-oxide hydrochloride，TMG） as a methyl donor to compensate for methyl group depletion during NAD+ metabolism, thereby optimizing both the NAD+ biosynthetic pathway and DNA methylation processes. This methyl compensatory mechanism exhibits NAD+ potentiating effects. Furthermore, the scientific integration of PQQ and coenzyme Q10 provides mitochondrial biogenesis support, enhancing mitochondrial density and functional capacity while synergistically augmenting NAD+ bioavailability.
Product Features：
Comprehensive support of the NAD+ metabolic pathway summarizes as:
1. NAD+ Metabolic Pathway Support；
2. Holistic Regulation of Mitochondrial Biogenesis Dynamics;
3. DNA Methylation-Mediated Genomic Stabilization.
Specification content
*TMG (Betaine Anhydrous), as a methyl donor, can complement in vivo methyl depletion caused by NAD+ metabolism.
Directions：As a dietary supplement for adults, take 2 capsules daily, preferably with a meal or as directed by a healthcare professional.
Packaging content：60 Capsules Dietary Supplement.30-Day Supply.
Does Not Contain：Sugar, Starch, Preservatives, Soy, Wheat, Gluten, Dairy.
Storage Conditions：Store in a cool, dry place away from direct sunlight.
Precautions：Do not use if the tamper-evident packaging is broken. Keep out of reach of children.
Shelf life：Three years.
WARNING： Do not take this product if you are pregnant or nursing. Consult a healthcare professional before taking this product if you have a medical condition or are taking any medications. Stop using and consult a healthcare professional in case of an adverse reaction.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Distributed by Perlonfo Nutrients Global Inc.
Wilmington, DE 19808 USA
This product has been manufactured in a FDA, cGMP andNSF certified facility.
