Perlonfo® EGT Antioxidant Cellular Defense Matrix （4-in-1）is a scientifically
supplement comprised of vitamin C, dihydroquercetin (DHQ), trans-resveratrol, and L-ergothioneine (EGT), designed to deliver comprehensive antioxidants at cellular level through multi-mechanistic pathways.
Mechanistic Characterization of Active Components
1. L-Ergothioneine (EGT)
o A naturally occurring, sulfur-containing amino acid which is exclusively biosynthesized by microbial species (bacteria/fungi),and functions as an endogenously retained cytoprotectant in humans.
o Unique capability of regulating mitochondrial functions.
§ Mediated by the OCTN-1 transporter (SLC22A4 gene product), enabling selective accumulation in mitochondria.
§ Demonstrated dual efficacy:
§ Direct ROS scavenging (IC50 = 1.8 μM for superoxide anion)
§ Mitochondrial membrane stabilization (29% reduction in lipid peroxidation at 10 μM)
2. Trans-Resveratrol
o A stilbenoid phytoalexin with demonstrated potency:
§ 10-fold higher per-radical quenching capacity vs. dietary polyphenols (ORAC: 14,500 μmol TE/g)
§ 34-fold enhanced glutathione recycling efficiency in vitro (NADPH depletion assay)
o Clinically validated pleiotropic effects:
§ Nrf2/ARE pathway activation (2.3-fold HO-1 upregulation at 50 μM)
§ Selective estrogen receptor modulation (ERα/ERβ binding affinity ratio: 1:12)
§ Chemopreventive activity via SIRT1-dependent apoptosis induction
3. Dihydroquercetin (DHQ/Taxifolin)
o Exhibits unmatched antioxidant capacity:
§ 350× vitamin E equivalence in lipid peroxidation inhibition (TBARS assay)
§ 500× vitamin C equivalence in aqueous-phase radical neutralization (ABTS assay)
o Forms a triphasic antioxidant network:
§ Regenerates oxidized vitamin C (reduction potential: +0.28 V)
§ Chelates pro-oxidant metals (Fe³+ binding constant: log K = 16.2)
§ Stabilizes mitochondrial Complex I (23% activity preservation under oxidative stress)
*Dihydroquercetin combined with Vitamin C has been approved as a prescription drug in some parts of the world.
Product Features：
1. Four-dimensional antioxidant protection with synergistic superpower.
2. A triple-action formula combining antioxidant, anti-inflammatory, and microcirculation-enhancing effects.
3. Clinically proven formulation supported by international evidence-based research.
4. GRAS-certified (Generally Recognized As Safe).
Specification content
*Dihydroquercetin combined with Vitamin C has been approved as a prescription drug in some parts of the world.
Directions: As a dietary supplement for adults, take 2 capsules daily, preferably with a meal or as directed by a healthcare professional.
Packaging content：60 Capsules Dietary Supplement.30-Day Supply.
Does Not Contain：Sugar, Starch, Preservatives, Soy, Wheat, Gluten, Dairy.
Storage Conditions：Store in a cool, dry place away from direct sunlight.
Precautions：Do not use if the tamper-evident packaging is broken. Keep out of reach of children.
Shelf life：Three years
WARNING：Do not take this product if you are pregnant or nursing. Consult a healthcare professional before taking this product if you have a medical condition or are taking any medications. Stop using and consult a healthcare professional in case of an adverse reaction.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Distributed by Perlonfo Nutrients Global Inc.
Wilmington, DE 19808 USA
This product has been manufactured in a FDA, cGMP andNSF certified facility.
